Recommended Testing For Autism

First Tier Testing

  1. Complete Blood Count with Differential
  2. Complete Metabolic Panel-liver and kidney function in particular
  3. Thyroid Panel (TSH, freeT4, freeT3)-low thyroid function is associated with cognitive, speech and developmental delays
  4. Cholesterol-low levels associated with irritability and hyperactivity
  5. Ferretin- low levels associated with insomnia, lower IQ and attention problems
  6. RBC minerals (Magnesium, Lithium, Zinc, Selenium)
  7. Vitamin D (25-OH) and Vitamin A
  8. Plasma Ammonia
  9. Lactate and Pyruvate
  10. Fasting Acyl Carnitine Levels
  11. C-Reactive Protein
  12. ESR
  13. Homocysteine Levels- to determine methylation defects
  14. Testosterone Levels (aggressive children only)
  15. Folate Receptor Antibodies (www.iliadneuro.com)
  16. Mitoswab - to determine mitochondrial dysfunction
  17. Urine Organic Acid Testing (www.genovadiagnostics.com
  18. Urinary Isoprostanes - increased levels consistent with oxidative stress
  19. Heavy Metal Testing- Mercury, Lead, Aluminum, Arsenic, Cadmium

Second Tier Testing

These tests should be considered once all of the first tier testing has been completed but there are still some obstacles to recovery.

  • IgG Food Allergy Testing
  • NeuroGenomic Profile - investigates Methylation, Detoxification and Oxidative stress
  • Comprehensive Digestive Stool Analysis 
  • Amino Acids (urine or plasma)
  • Lyme Disease Testing 
  • Adrenal Stress Testing
  • Heavy Metal Testing (Urine, Stool or Hair)
  • Immune System Panel- including vaccine titers, ANA, Antigliadin antibodies (elevated in some with celiac disease and cross react with Purkinje cells in cerebellum)

neurotransmitter testing

Many times investigation into the specifics of neurotransmitter function can be invaluable in the treatment process, especially when dealing with co morbid issues like anxiety, depression, OCD, panic disorders and ADD/ADHD. New revelations in epigenetics and laboratory testing now allows clinicians to pinpoint the neurotransmitter (seretonin, epinephrine, norepinephrine, acetylcholine or dopamine) imbalances in the brain.

 

 

 

 

 

For instance, if a child is suffering from high dopamine levels one would expect to see the following symptoms:

  • anxiety
  • chronic pain
  • constant worry
  • delirium
  • increased heart beats or tachycardia
  • high blood pressure
  • insomnia
  • paranoia
  • schizophrenia

While in contrast, those suffering from low dopamine levels, would be dealing with the following:

  • cravings
  • hyperactivity
  • anger
  • substance abuse
  • high risk behaviour
  • impulsivity
  • addictions

Now, with the help of doctor's data and the neurobiogenic amines test the complex web of neurotransmitter metabolism  and its effects on brain function are no longer a mystery. Urinary levels of neurotransmitter metabolites can be measured and used as a functional test for 2 important enzymes (COMT and MAO). Many environmental stressers can affect the function of these enzymes. For example, a lack of nutritional co factors (vitamin, minerals) required for normal enzyme function may decrease COMT/MAO function and hence skew neurotransmitter balance in the brain. In addition, dietary indiscretions like high sodium intake, environmental toxins, infections and tobacco use can also negatively impact neurotransmitter enzyme activity.